Uridine diphosphate-glucuronosyltransferase 2B15 D85Y gene polymorphism is associated with lower prostate cancer risk: a systematic review and meta-analysis
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Uridine diphosphate-glucuronosyltransferase 2B15 D85Y gene polymorphism is associated with lower prostate cancer risk: a systematic review and meta-analysis
UGT2B15 (uridine diphosphate-glucuronosyltransferase 2B15) catalyzes the conversion of lipophilic C19 steroid androgens such as dihydrotestosterone (DHT) into water-soluble metabolites that can be excreted. Studies of the association between the UGT2B15 gene D85Y polymorphism and prostate cancer have yielded contradictory results. We therefore systematically searched in the PubMed, EMBASE, Scie...
متن کاملA polymorphism in the UDP-Glucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk.
Introduction UGT, a family of Phase II detoxification enzymes, catalyzes the transfer of the glucuronyl group from uridine diphosphogluronic acid to many substrates, including steroid hormones (1). Glucuronidation, an irreversible step in the pathway of steroid metabolism, converts steroids into polar, water soluble derivatives and may alter the levels of active androgens in steroid target tiss...
متن کاملNull Results in Brief A Polymorphism in the UDP-Glucuronosyltransferase 2B15 Gene (DY) Is Not Associated with Prostate Cancer Risk
Introduction UGT, a family of Phase II detoxification enzymes, catalyzes the transfer of the glucuronyl group from uridine diphosphogluronic acid to many substrates, including steroid hormones (1). Glucuronidation, an irreversible step in the pathway of steroid metabolism, converts steroids into polar, water soluble derivatives and may alter the levels of active androgens in steroid target tiss...
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Objective(s):Genome-wide association studies have identified a number of genetic variants of telomerase reverse transcriptase (TERT), cleft lip and palate transmembrane1-like (CLPTM1L) associated with the risk of bladder cancer. Rs401681 polymorphism in TERT-CLPTM1L was of special interest for bladder cancer risk, whereas the results were inconclusive. Materials and Methods:Publications illustr...
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The association between Guanine Nucleotide Binding protein β protein polypeptide 3(GNB3) C825T polymorphism and obesity has recently been reported. However, the findings remain inconclusive. The aim of this systematic review and meta-analysis was to detect the relationship between GNB3 C825T polymorphism and obesity. Materials and Methods: Six electronic databases including Embase, Medlin...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.17375